P A T H W A Y - C O N N E C T O R   V:1.0.0
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 1. Select Database and Organism

 2. Upload your Files

    • List of genes (Enrichment analysis will follow)
    • List of human KEGG's pathway IDs
    • List of human Reactome's pathway IDs
    • List of mouse Protein IDs

      2a. Enrichment Settings

     3. Create Complementary Network


     Original NET: direct connections within the reference NET

     Get Edge List View in new Window Network Stats

     Complementary NET:

     Get Edge List View in new Window Network Stats

      PathwayConnector: Finding complementary pathways to enhance functional analysis

    Minadakis, G., & Spyrou, G. M. (2021). A Systems Bioinformatics Approach to Interconnect Biological Pathways. In Computational Methods in Synthetic Biology (pp. 231-249). Humana, New York, NY.

    Minadakis, G., Zachariou, M., Oulas, A., & Spyrou, G. M. (2018). PathwayConnector: Finding complementary pathways to enhance functional analysis. Bioinformatics, 35(5), 889-891.

    Zachariou, M., Minadakis, G., Oulas, A., Afxenti, S., & Spyrou, G. M. (2018). Integrating multi-source information on a single network to detect disease-related clusters of molecular mechanisms. Journal of proteomics, 188, 15-29.

    Kakouri, A. C., Christodoulou, C. C., Zachariou, M., Oulas, A., Minadakis, G., Demetriou, C. A., ... & Spyrou, G. M. (2019). Revealing Clusters of Connected Pathways Through Multisource Data Integration in Huntington's Disease and Spastic Ataxia. IEEE journal of biomedical and health informatics, 23(1), 26-37

    Gkretsi, V., Louca, M., Stylianou, A., Minadakis, G., Spyrou, G., & Stylianopoulos, T. (2019). Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15). International journal of molecular sciences, 20(1), 163.

    Department of Bioinformatics, The Cyprus Institute of Neurology & Genetics. © 2021
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